Search on: INSULIN-LIKE GROWTH FACTOR I 
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Descriptor English:   Insulin-Like Growth Factor I 
Descriptor Spanish:   Factor I del Crecimiento Similar a la Insulina 
Descriptor Portuguese:   Fator de Crescimento Insulin-Like I 
Synonyms English:   IGF-I
Somatomedin C  
Tree Number:   D12.644.276.937.400
D12.776.124.862.400
D12.776.467.937.400
D23.529.937.400
Definition English:   A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor. 
See Related English:   Receptor, IGF Type 1
 
History Note English:   91(86); was see under SOMATOMEDINS 1986-90 
Allowable Qualifiers English:  
analogs & derivatives administration & dosage
adverse effects agonists
antagonists & inhibitors analysis
biosynthesis cerebrospinal fluid
chemistry classification
chemical synthesis contraindications
drug effects deficiency
diagnostic use economics
genetics history
immunology isolation & purification
metabolism pharmacology
physiology pharmacokinetics
poisoning radiation effects
supply & distribution secretion
standards toxicity
therapeutic use ultrastructure
urine  
Record Number:   22312 
Unique Identifier:   D007334 

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